Dental Pulp Stem Cells Enhance Scaffold-Based Jaw Bone Regeneration

ABSTRACT

Regenerative Potential of Human Dental Pulp Stem Cells in Scaffold-Based Alveolar and Jaw Bone Reconstruction: A Systematic Review.
BMC Oral Health. 2025 Jul 2;25(1):986. doi: 10.1186/s12903-025-06368-6.

Alshaibani DA, Kamadjaja MJ, Sitalaksmi RM, Ridwan RD, Al-Gabri RS, Zafar MS, Ramalingam S, Alqutaibi AY.

Author information
Department of Prosthetic Dental Sciences and affiliated dental research centers in Saudi Arabia.
Faculty of Dental Medicine, Airlangga University, Surabaya, Indonesia.
Departments of Oral and Maxillofacial Surgery, Regenerative Dentistry, and Biomaterials Research at collaborating institutions in Indonesia, Saudi Arabia, and Malaysia.

BACKGROUND: Bone loss in the alveolar ridge and jaw can complicate implant placement and oral rehabilitation. Human dental pulp stem cells (DPSCs) have emerged as a promising cell source for tissue engineering because of their osteogenic potential and accessibility.

METHODS: The authors conducted a systematic review following PRISMA guidelines to evaluate studies investigating human DPSCs or SHEDs combined with scaffold materials for alveolar and jaw bone regeneration.

RESULTS: Studies consistently demonstrated that combining DPSCs or SHEDs with scaffolds improved bone regeneration compared with scaffold-only approaches. Improvements were observed in bone volume, bone density, osteogenesis, angiogenesis, and tissue integration across animal models.

CONCLUSIONS: This review showed that integrating dental pulp stem cells with scaffolds significantly enhances alveolar and jaw bone regeneration and supports their future application in craniofacial tissue engineering and regenerative dentistry.

PMID: 40604687
PMCID: PMC12220678
DOI: 10.1186/s12903-025-06368-6