Dental Pulp Stem Cells Drive Advances in Pulp Regeneration Therapy

ABSTRACT

Research Progress of Dental Pulp Regeneration Treatment.
World Journal of Stem Cells. 2024. doi: 10.11817/j.issn.1672-7347.2024.240011.

Luo Z, Yu M, Shen T.

Author information
Department of Endodontics, Xiangya Stomatological Hospital, Central South University, Changsha, China.
School of Stomatology, Central South University, Changsha, China.

BACKGROUND: Conventional root canal therapy effectively eliminates infection but does not restore living pulp tissue. Dental pulp regeneration aims to regenerate functional pulp tissue capable of maintaining tooth vitality.

METHODS: The authors reviewed advances in regenerative endodontics, including stem cell transplantation, cell homing strategies, scaffold technologies, and growth factor-based therapies.

RESULTS: Studies demonstrated that dental pulp stem cells can contribute to vascularized pulp-like tissue formation, dentin regeneration, and restoration of pulp vitality. Advances in tissue engineering have significantly improved regenerative outcomes.

CONCLUSIONS: This review showed that dental pulp stem cells remain central to future regenerative endodontic therapies and may transform the treatment of pulp injuries and disease.

PMID: 39311795
PMCID: PMC11420962
DOI: 10.11817/j.issn.1672-7347.2024.240011