Dental Pulp Stem Cells Advance Regenerative Medicine Applications

ABSTRACT

Dental Pulp Stem Cells: Basic Research and Future Application in Regenerative Medicine.
Biomedicine & Pharmacotherapy. 2024 Sep;178:116990. doi: 10.1016/j.biopha.2024.116990.

Stefa?ska K, Volponi AA, Kulus M, Wa?ko J, Farzaneh M, Grzelak J, Azizidoost S, Mozdziak P, Bukowska D, Antosik P, Zabel M, Podhorska-Oko?ów M, Dzi?giel P, Szczesniak M, Woszczyk M, Kempisty B.

Author information
Department of Histology and Embryology, Wroclaw Medical University, Wroclaw, Poland.
Centre for Craniofacial and Regenerative Biology, King's College London, London, United Kingdom.
Department of Animal Physiology and Development, Pozna? University of Life Sciences, Pozna?, Poland.
Additional collaborating institutions in Poland and the United Kingdom.

BACKGROUND: Dental pulp stem cells (DPSCs) are multipotent stem cells capable of self-renewal and differentiation into a variety of cell types. Their accessibility, regenerative potential, and immunomodulatory properties have made them an attractive source for regenerative medicine.

METHODS: The authors reviewed current knowledge regarding DPSC biology, differentiation capacity, regenerative mechanisms, and therapeutic applications across multiple fields of medicine.

RESULTS: Studies demonstrated that DPSCs can contribute to bone regeneration, neural repair, angiogenesis, wound healing, and immune regulation. The review also highlighted the therapeutic potential of DPSC-derived extracellular vesicles and exosomes.

CONCLUSIONS: This review showed that dental pulp stem cells possess broad regenerative capabilities and may play an important role in future regenerative medicine therapies.

PMID: 39024839
DOI: 10.1016/j.biopha.2024.116990