Dental Pulp Stem Cells Accelerate Tissue Repair and Wound Healing

ABSTRACT

Tissue Repair Mechanisms of Dental Pulp Stem Cells: A Comprehensive Review from Cutaneous Regeneration to Mucosal Healing.
Curr Issues Mol Biol. 2025;47(7):509. doi: 10.3390/cimb47070509.

He J, Fu J, Wang R, Liu X, Yao J, Xing W, Wang X, He Y.

Author information
1.First Clinical College of the Ministry of Medicine, Wuhan University of Science and Technology, Wuhan, China.
2.Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, China.

BACKGROUND: Effective wound healing requires inflammation control, angiogenesis, and tissue remodeling. Dental pulp stem cells have emerged as a promising tool for promoting tissue repair.

METHODS: The authors reviewed studies investigating the mechanisms through which dental pulp stem cells contribute to cutaneous and mucosal healing.

RESULTS: Studies showed that dental pulp stem cells promote wound healing through immune regulation, angiogenesis, extracellular matrix remodeling, and paracrine signaling.

CONCLUSIONS: This review showed that dental pulp stem cells may support tissue repair and wound healing across multiple tissue types. Future studies may help expand their role in regenerative medicine.

PMID: 40728978
PMCID: PMC12293388
DOI: 10.3390/cimb47070509