Dental-Derived Stem Cells Promote Functional Pulp Regeneration

ABSTRACT

Angiogenic and Neurogenic Potential of Dental-Derived Stem Cells for Functional Pulp Regeneration: A Narrative Review.
International Endodontic Journal. 2025 Mar;58(3):391-410. doi: 10.1111/iej.14180.

Su W, Liao C, Liu X.

Author information
School of Stomatology, Jinan University, Guangzhou, China.
Departments of Endodontics and Regenerative Dentistry, affiliated academic institutions in China.

BACKGROUND: Successful pulp regeneration requires more than dentin formation. Regenerated pulp tissue must also establish a functional blood supply and neural network. Dental-derived stem cells have demonstrated the ability to support both angiogenesis and neurogenesis during tissue regeneration.

METHODS: The authors reviewed current evidence regarding the angiogenic and neurogenic properties of dental-derived stem cells and their applications in regenerative endodontics and pulp tissue engineering.

RESULTS: Studies demonstrated that dental-derived stem cells promote vascularization through the secretion of angiogenic factors and support neural regeneration through neurotrophic signaling pathways. These mechanisms contribute to the formation of functional, living pulp tissue capable of long-term survival and repair.

CONCLUSIONS: This review showed that dental-derived stem cells possess significant angiogenic and neurogenic capabilities that are critical for functional pulp regeneration. Continued advances in stem cell biology and tissue engineering may help accelerate the development of clinically successful regenerative endodontic therapies.

PMID: 39660369
DOI: 10.1111/iej.14180